Amphiphilic shuttle peptide delivers base editor ribonucleoprotein to correct the CFTR R553X mutation in well-differentiated airway epithelial cells

SCGE researchers created a novel amphiphilic shuttle peptide, S237, based on the previously reported S10 peptide, and found that S237 achieved a 4.6-fold increase in base editor RNP delivery. https://t.co/6PErFaRdXE

👏READ: “Amphiphilic shuttle peptide delivers base editor ribonucleoprotein to correct the CFTR R553X mutation in well-differentiated airway epithelial cells.” Kulhankova et al., Nucleic Acid Research, 2024. (ORIP support through U42OD027090) https://t.c…

"Amphiphilic shuttle peptide delivers base editor ribonucleoprotein to correct the CFTR R553X mutation in well-differentiated airway epithelial cells" Kulhankova K, Cheng AX, Traore S [..] Guay D. Nucleic Acids Res. 2024-09-24. https://t.co/KLc3AZP6ql #…