Tablets which were binary mixtures of pioglitazone hydrochloride (PioHCl) with magnesium stearate (MgSt), croscarmellose sodium (CCS), microcrystalline cellulose or lactose monohydrate were prepared. Two sets of experiments, using intact tablets, were performed. (i) Tablets containing PioHCl (90% w/w) and MgSt were exposed to 25 or 40 °C and 75% RH in a custom built temperature/humidity chamber. In situ spatio-temporal mapping of disproportionation was performed by transmission mode synchrotron X-ray diffractometry (SXRD; Argonne National Labs). Tablets were scanned in radial direction starting from top edge of the tablet and moving, in increments of 300 µm, towards the center. There was evidence of disproportionation after 10 minutes (at 40 °C). The reaction was initiated on the tablet surface and progressed toward the core. (ii) SXRD of tablets stored for longer time (up to 15 days) enabled the simultaneous quantification of the reactants and products of disproportionation and provided insight into the reaction progression. The influence of sorbed water and microenvironmental acidity on the disproportionation reaction was investigated. The most pronounced reaction was observed in presence of MgSt followed by CCS. The transformation was solution-mediated and the spatial heterogeneity in disproportionation could be explained by the migration of sorbed water. There was a good correlation between microenvironmental acidity (pHeq) and extent of PioHCl disproportionation.
Pharmacology, Toxicology and Pharmaceutical Science
10
27%
Chemical Engineering
1
3%
Computer Science
1
3%
Social Sciences
1
3%
Other
1
3%
Unknown
12
32%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2017.
All research outputs
#20,356,726
of 25,837,817 outputs
Outputs from Molecular Pharmaceutics
#2,920
of 4,616 outputs
Outputs of similar age
#240,422
of 326,835 outputs
Outputs of similar age from Molecular Pharmaceutics
#53
of 108 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,616 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
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We're also able to compare this research output to 108 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
