Title |
Involvement of GABAA Receptors in the Neuroprotective Effect of Theanine on Focal Cerebral Ischemia in Mice
|
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Published in |
Journal of Pharmacological Sciences, October 2007
|
DOI | 10.1254/jphs.scz070901 |
Pubmed ID | |
Authors |
Nobuaki Egashira, Kazuhide Hayakawa, Megumi Osajima, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara |
Abstract |
We investigated the involvement of gamma-aminobutyric acid(A) (GABA(A)) receptors in the neuroprotective effect of gamma-glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. Theanine (1 mg/kg) reduced the size of the cerebral infarct and alterations of NeuN, GFAP, and Iba 1 expression levels at 24 h after MCA occlusion. This neuroprotective effect of theanine was prevented by bicuculline (GABA(A)-receptor antagonist, 10 mg/kg) but not 3-mercaptopropionic acid (glutamate decarboxylase inhibitor). These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABA(A) receptors. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 2% |
Unknown | 45 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 8 | 17% |
Researcher | 8 | 17% |
Student > Bachelor | 4 | 9% |
Student > Ph. D. Student | 4 | 9% |
Student > Master | 4 | 9% |
Other | 7 | 15% |
Unknown | 11 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 7 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 13% |
Neuroscience | 5 | 11% |
Medicine and Dentistry | 4 | 9% |
Nursing and Health Professions | 3 | 7% |
Other | 9 | 20% |
Unknown | 12 | 26% |