Crystallography first in fragment optimization: Binding-Site Purification of Actives (B-SPA)
Practical Fragments,
At FBLD 2024, Frank von Delft (Diamond Light Source) announced the ambitious goal of taking a 100 µM binder to a 10 nM lead…
Binding‐Site Purification of Actives (B‐SPA) Enables Efficient Large‐Scale Progression of Fragment Hits by Combining Multi‐Step Array Synthesis With HT Crystallography
Overview of attention for article published in Angewandte Chemie. International Edition, March 2025
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