Binding‐Site Purification of Actives (B‐SPA) Enables Efficient Large‐Scale Progression of Fragment Hits by Combining Multi‐Step Array Synthesis With HT Crystallography

Overview of attention for article published in Angewandte Chemie. International Edition, March 2025

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In the top 25% of all research outputs scored by Altmetric
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RP @haroldgrosjean.bsky.social: 🚨 Binding-Site Purification of Actives 🦾 With robotic chemistry, automated QC & HT crystallography, we skip purification for faster, greener, cheaper SAR and DMTA-cycles! 🔗 doi.org/10.1002/anie... Thanks to @diamondli…

🚨 Binding-Site Purification of Actives 🦾 With robotic chemistry, automated QC & HT crystallography, we skip purification for faster, greener, cheaper SAR and DMTA-cycles! 🔗 doi.org/10.1002/anie... Thanks to @diamondlightsource.bsky.social @oxfordbio…

RP @philbiggin.bsky.social: Congratulations to Harold Grosjean, Anthony Aimon, Storm Hassell-Hart and Warren Thompson, on their latest work appearing in @angewandtechemie.bsky.social, where small-molecule binders can be extracted directly from crude-rea…

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