Development and pharmacological characterization of novel multi‐ calcitonin gene‐related peptide and pituitary adenylate cyclase‐activating peptide receptor antagonists

Researchers in this study created multi-receptor antagonists that can simultaneously block both CGRP and PACAP receptor signaling pathways implicated in migraine pathophysiology. This offers a more effective therapeutic approach than targeting either pathway alone.

User CerebralTorque, in the Cerebral Torque subreddit, 26 Feb 2025