Activation of XBP1s attenuates disease severity in models of proteotoxic Charcot–Marie–Tooth type 1B

Overview of attention for article published in Brain, February 2025

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Touvier et al. investigate the role of the UPR transcription factor XBP1s in models of proteotoxic Charcot–Marie–Tooth type 1B. Activation of XBP1s limits Schwann cell demyelination – enhancing its activity could be a promising therapeutic approach. tinyu…

RP @medicine.stitches.today: Activating XBP1s significantly alleviates disease severity in Charcot-Marie-Tooth type 1B models by enhancing Schwann cell proteostasis. by Touvier T, Veneri FA (...) D'Antonio M et 13 al. in Brain #MedSky 📖 read the articl…

Activating XBP1s significantly alleviates disease severity in Charcot-Marie-Tooth type 1B models by enhancing Schwann cell proteostasis. by Touvier T, Veneri FA (...) D'Antonio M et 13 al. in Brain #MedSky 📖 read the article:

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