Structural basis of gap-filling DNA synthesis in the nucleosome by DNA Polymerase β

Overview of attention for article published in Nature Communications, March 2025

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In the top 25% of all research outputs scored by Altmetric
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The Artist of Life’s Blueprint This enzyme acts as a sculptor, gently bending DNA to mend gaps with the quiet grace of a soft rain. https://t.co/eMcQMBfEMR https://t.co/5vqgwunTH6

Check out the April @EMGSUS Member research highlight featuring the paper "Structural basis of gap-filling DNA synthesis in the nucleosome by DNA Polymerase β" by @tylermweaver1 and @Freudlab https://t.co/Mm8bxMhHPp https://t.co/Q1xdqbXmcK

To heal breaks hidden in the nucleosome's tight embrace, Pol β acts as a molecular sculptor, bending DNA into a 90° arc. Through this graceful dance of "sculpting," the enzyme transforms a rigid barrier into the perfect stage for life’s repair. https://t…

Discover insights from 1-nt gap repair by DNA Pol β in chromatin! Using biochemical assays and cryo-EM, this study unravels the complex mechanisms in 123 characters. PMID:40097433, Nat Commun 2025, @NatureComms https://t.co/JBGO47gIEY #AI #Pharma #BioMed …

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