⭕ Plasmids of the group lncP-1 replicate and usually persist in many bacteria, but nothing in nature comes without exception. The lncP-1𝛃 plasmid pBP136 became extinct in E.coli at the lab. Scientists from the @uidaho.bsky.social suspect which gene is gu…
Evolution of a Plasmid Regulatory Circuit Ameliorates Plasmid Fitness Cost | Molecular Biology and Evolution | Oxford Academic https://academic.oup.com/mbe/article/42/4/msaf062/8095365?login=false
Elg et al. show how a single gene, upf31, determines plasmid stability in E. coli. Experimental evolution indicated that inactivating upf31 led to the rewiring of regulatory interactions and improved persistence of IncP-1β plasmid pBP136 in E. coli. 🔗 d…
RRIDs were included in this Molecular Biology and Evolution paper. Thanks for making your methods matter! #STMpublishing #ReproducibleResearch #RRID