Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, April 2025

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A new inhibitor targeting a key efflux pump in Mycobacterium tuberculosis has been identified, alongside the first complete structural map of the pump, advancing efforts against drug-resistant tuberculosis. doi.org/g9m4gv

RP @mattmcneil86.bsky.social: Super excited that this manuscript investigating verapamil potentiation of bedaquiline in M. tuberculosis is now in PNAS!! Great collaborative effort with Lalita Ramakrishnan and her team at the MRC-LMB!! www.pnas.org/doi/…

RRIDs were included in this Proceedings of the National Academy of Sciences paper. Thanks for making your methods matter! #OpenScience #OpenScience #RRID

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