You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling
|
|---|---|
| Published in |
Molecular & Cellular Endocrinology, August 2013
|
| DOI | 10.1016/j.mce.2013.08.009 |
| Pubmed ID | |
| Authors |
Darko Stevanovic, Vladimir Trajkovic, Sabrina Müller-Lühlhoff, Elisabeth Brandt, William Abplanalp, Christiane Bumke-Vogt, Beate Liehl, Petra Wiedmer, Kristina Janjetovic, Vesna Starcevic, Andreas F.H. Pfeiffer, Hadi Al-Hasani, Matthias H. Tschöp, Tamara R. Castañeda |
| Abstract |
Signaling through the mammalian target of rapamycin complex 1 (mTORC1) and its effectors the S6-kinases (S6K) in the hypothalamus is thought to be involved in nutrient sensing and control of food intake. Given the anatomical proximity of this pathway to circuits for the hormone ghrelin, we investigated the potential role of the mTORC1/S6K pathway in mediating the metabolic effects of ghrelin. We found that ghrelin promoted phosphorylation of S6K1 in the mouse hypothalamic cell line N-41 and in the rat hypothalamus after intracerebroventricular administration. Rapamycin, an inhibitor of mTORC1, suppressed ghrelin-induced phosphorylation of hypothalamic S6K1 and increased food intake and insulin in rats. Chronic peripheral administration of ghrelin induced a significant increase in body weight, fat mass and food efficiency in wild-type and S6K2-knockout but not in S6K1-knockout mice. We therefore propose that ghrelin-induced hyperphagia, adiposity and insulin secretion are controlled by a central nervous system involving the mTORC1/S6K1 pathway. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Serbia | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 39 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 27% |
| Student > Master | 6 | 15% |
| Student > Doctoral Student | 4 | 10% |
| Professor > Associate Professor | 3 | 7% |
| Researcher | 3 | 7% |
| Other | 8 | 20% |
| Unknown | 6 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 34% |
| Medicine and Dentistry | 6 | 15% |
| Biochemistry, Genetics and Molecular Biology | 6 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
| Unspecified | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 9 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2013.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Molecular & Cellular Endocrinology
#2,275
of 2,949 outputs
Outputs of similar age
#160,842
of 212,161 outputs
Outputs of similar age from Molecular & Cellular Endocrinology
#34
of 40 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,949 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,161 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.