Factor H-related 1 and heparan sulfate architecture contribute to complement dysregulation in C3 glomerulopathy

Overview of attention for article published in Frontiers in immunology, May 2025

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Altered heparan sulphate architecture causes FHR-1 to disrupt FH function, increasing complement activation on mesangial cells. This is similar to how GAG changes in the blood/retinal barrier affect complement activity. #GAGs #FHRs #complement buff.ly/N…

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