| Title |
The increase of microRNA-21 during lung fibrosis and its contribution to epithelial-mesenchymal transition in pulmonary epithelial cells
|
|---|---|
| Published in |
Respiratory Research, September 2013
|
| DOI | 10.1186/1465-9921-14-95 |
| Pubmed ID | |
| Authors |
Mitsuhiro Yamada, Hiroshi Kubo, Chiharu Ota, Toru Takahashi, Yukiko Tando, Takaya Suzuki, Naoya Fujino, Tomonori Makiguchi, Kiyoshi Takagi, Takashi Suzuki, Masakazu Ichinose |
| Abstract |
The excess and persistent accumulation of fibroblasts due to aberrant tissue repair results in fibrotic diseases such as idiopathic pulmonary fibrosis. Recent reports have revealed significant changes in microRNAs during idiopathic pulmonary fibrosis and evidence in support of a role for microRNAs in myofibroblast differentiation and the epithelial-mesenchymal transition in the context of fibrosis. It has been reported that microRNA-21 is up-regulated in myofibroblasts during fibrosis and promotes transforming growth factor-beta signaling by inhibiting Smad7. However, expression changes in microRNA-21 and the role of microRNA-21 in epithelial-mesenchymal transition during lung fibrosis have not yet been defined. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 3% |
| Mexico | 1 | 1% |
| Japan | 1 | 1% |
| Unknown | 72 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 20% |
| Student > Ph. D. Student | 11 | 14% |
| Student > Bachelor | 7 | 9% |
| Student > Master | 6 | 8% |
| Student > Doctoral Student | 4 | 5% |
| Other | 19 | 25% |
| Unknown | 14 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 22% |
| Agricultural and Biological Sciences | 16 | 21% |
| Biochemistry, Genetics and Molecular Biology | 12 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
| Unspecified | 3 | 4% |
| Other | 6 | 8% |
| Unknown | 19 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2013.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Respiratory Research
#2,702
of 3,062 outputs
Outputs of similar age
#162,150
of 215,075 outputs
Outputs of similar age from Respiratory Research
#17
of 25 outputs
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