Templating of monomeric alpha-synuclein results in inflammation and SNpc dopamine neuron death in a genetic mouse model of induced synucleinopathy

Overview of attention for article published in Scientific Reports, July 2025

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In normal mice, injection of pre-formed fibrils (PFFs), but not monomeric α-synuclein = aggregated α-syn, loss of substantia nigra dopamine neurons & increased neuroinflammation In A53T SNCA mice, both PFFs & monomeric α-synuclein induced this pathology …

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