Cryptic intronic transcriptional initiation generates efficient endogenous mRNA templates for C9orf72-associated RAN translation

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, August 2025

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RRIDs were included in this in Proceedings of the National Academy of Sciences paper. RRIDs improve reproducibility in scientific research. #methodsmatter #ReproducibleResearch #accelerateopenscience

RP @realtoddlab.bsky.social: Ever wonder how intronic repeats in C9orf72 get translated into toxic proteins in ALS and FTD? We found that transcription initiates within the intron to generate a novel endogenous efficient mRNA template for RAN translatio…

Ever wonder how intronic repeats in C9orf72 get translated into toxic proteins in ALS and FTD? We found that transcription initiates within the intron to generate a novel endogenous efficient mRNA template for RAN translation in patient neurons and mous…

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