Kristen L. Knutson, Donghong Wu, Sanjay R. Patel, Jose S. Loredo, Susan Redline, Jianwen Cai, Linda C. Gallo, Yasmin Mossavar-Rahmani, Alberto R. Ramos, Yanping Teng, Martha L. Daviglus, Phyllis C. Zee

Recent studies implicate inadequate sleep duration and quality in metabolic disease. Fewer studies have examined the timing of sleep, which may be important because of its potential impact on circadian rhythms of metabolic function. We examined the association between sleep timing and metabolic risk among Hispanic/Latino adults. Cross-sectional data from community-based study of 13,429 participants aged 18-74 years. People taking diabetes medications were excluded. Sleep timing was determined from self-reported bedtimes and wake times. Chronotype was defined as the midpoint of sleep on weekends adjusted for sleep duration on weekdays. Other measurements included body mass index (BMI), fasting glucose levels, estimated insulin resistance (HOMA-IR), glucose levels 2 hours post oral glucose ingestion, and hemoglobin A1c. Survey linear regression models tested associations between sleep timing and metabolic measures. Analyses were stratified by diabetes status and age group when significant interactions were observed. Among participants with diabetes, fasting glucose levels were positively associated with bedtime (approximately +3%/hour later, p<.01) and midpoint of sleep (approximately +2%/hour later, p<.05). In participants with and without diabetes combined, HOMA-IR was positively associated with midpoint of sleep (+1.5%/hour later, p<.05), and chronotype (+1.2%/hour later, p<.05). Associations differed by age group. Among those <36 years, later sleep timing was associated with lower BMI, lower fasting glucose, and lower HbA1c, but the opposite association was observed among older participants. Later sleep timing was associated with higher estimated insulin resistance across all groups. Some associations between sleep timing and metabolic measures may be age-dependent.