IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo via eicosanoid signalling

University of Iowa scientists studied IL-13 in COVID-19. In human airway cells IL-13 reduced infection by lowering ACE2-positive ciliated cells. But in mice IL-13 worsened disease by boosting harmful eicosanoid signaling. www.thelancet.com/journals/e…