37 followers
RT @Dr_Oncologista: AMALEE Trial | Ribociclib Dose Refinement in HR+/HER2– MBC A high-quality phase 3b trial comparing ribociclib 400 mg…
10,263 followers
The ORR endpoint here makes non-inferiority easy to miss (even though PFS identical). Maybe this is an outlier for systemic de-escalation trial design, but RT NI trials (~PROSPECT) tend to use later event-based endpts (DFS), hence NI more attainable/RT “…
10,263 followers
The ORR endpoint here makes non-inferiority easy to miss (even though PFS identical). Maybe this is an outlier for systemic de-escalation trial design, but RT NI trials ( ~PROSPECT) tend to use later event-based endpts (DFS), hence NI more attainable/RT …
243 followers
RT @Dr_Oncologista: AMALEE Trial | Ribociclib Dose Refinement in HR+/HER2– MBC A high-quality phase 3b trial comparing ribociclib 400 mg…