RNF114, a RING E3 ligase that reads and extends the hybrid ADP-ribose-ubiquitin signal

Overview of attention for article published in EMBO Journal, October 2025

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And big thanks to Adam Middleton and Catherine Day for the awesome News & Views! www.embopress.org/doi/full/10....

Latest publication from Otago Biochemistry RNF114, a RING E3 ligase that reads and extends the hybrid ADP-ribose-ubiquitin signal www.embopress.org/doi/full/10....

This News & Views article provides a nice overview of the recent discoveries that RNF114 recognizes a dual modification ADP-ribose–ubiquitin (ADPr-Ub) and subsequently extends it by adding additional ubiquitin units.: pubmed.ncbi.nlm.nih.gov/41039156/

See also the nice commentary by Middleton & Day highlighting the new @embojournal.org article as well as three related reports! www.embopress.org/doi/full/10....

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