It has been postulated that homeostatic mechanisms maintain stable circuit function by keeping neuronal firing within a set point range, but such firing rate homeostasis has never been demonstrated in vivo. Here we use chronic multielectrode recordings to monitor firing rates in visual cortex of freely behaving rats during chronic monocular visual deprivation (MD). Firing rates in V1 were suppressed over the first 2 day of MD but then rebounded to baseline over the next 2-3 days despite continued MD. This drop and rebound in firing was accompanied by bidirectional changes in mEPSC amplitude measured ex vivo. The rebound in firing was independent of sleep-wake state but was cell type specific, as putative FS and regular spiking neurons responded to MD with different time courses. These data establish that homeostatic mechanisms within the intact CNS act to stabilize neuronal firing rates in the face of sustained sensory perturbations.
This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2024.
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#1,621,380
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#2,553
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#12,587
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Outputs of similar age from Neuron
#43
of 132 outputs
Altmetric has tracked 32,807,097 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,658 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.4. This one has done well, scoring higher than 75% of its peers.
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We're also able to compare this research output to 132 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
