Title |
Assembly of Amphiphilic Baskets into Stimuli-Responsive Vesicles. Developing a Strategy for the Detection of Organophosphorus Chemical Nerve Agents
|
---|---|
Published in |
Journal of the American Chemical Society, September 2013
|
DOI | 10.1021/ja408585j |
Pubmed ID | |
Authors |
Shigui Chen, Yian Ruan, Jason D. Brown, Judith Gallucci, Veselin Maslak, Christopher M. Hadad, Jovica D. Badjić |
Abstract |
We designed basket 1 to comprise a C3-symmetric hydrophobic cage (477 Å(3)) at its southern edge and three polar ammonium caps at the northern edge. This amphiphilic molecule was observed to assemble into large unilamellar vesicles (350 nm, TEM) in water and thereby entrap dimethyl phenylphosphonate (184 Å(3)) in its cavity (K(app) = (1.97 ± 0.02) × 10(3) M(-1)). The entrapment of the organophosphonate, akin to soman in size (186 Å(3)), triggers the transformation of the vesicular material into nanoparticles (100 nm, TEM). Stimuli-responsive vesicles, containing baskets of type 1 in their bilayer membrane, are unique assemblies and important for obtaining novel sensing devices. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 2% |
Unknown | 47 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 35% |
Researcher | 10 | 21% |
Student > Bachelor | 7 | 15% |
Student > Doctoral Student | 5 | 10% |
Other | 2 | 4% |
Other | 3 | 6% |
Unknown | 4 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 37 | 77% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Agricultural and Biological Sciences | 1 | 2% |
Sports and Recreations | 1 | 2% |
Physics and Astronomy | 1 | 2% |
Other | 2 | 4% |
Unknown | 5 | 10% |