Prolonged exposure to teixobactin generates cross-tolerance to other cell wall-targeting antimicrobials in Enterococcus faecalis

Overview of attention for article published in Antimicrobial Agents and Chemotherapy, November 2025

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RP @smitslab.bsky.social: Prolonged exposure to teixobactin generates cross-tolerance to other cell wall-targeting antimicrobials in Enterococcus faecalis | Antimicrobial Agents and Chemotherapy journals.asm.org/doi/10.1128/...

Prolonged exposure to teixobactin generates cross-tolerance to other cell wall-targeting antimicrobials in Enterococcus faecalis | Antimicrobial Agents and Chemotherapy journals.asm.org/doi/10.1128/...

Enterococcus faecalis shows ↑ tolerance to teixobactin (TXB) after prolonged exposure, not resistance. Mutations in cell envelope/stress pathways found; liaFSR system key in tolerance. 🦠🔬 #idsky

RP @rachel-darnell19.bsky.social: New paper out in AAC looking at the development of hyper-tolerance and cross-tolerance to cell wall-targeting antimicrobials via mutations in the mevalonate and Epa biosynthesis pathways and the LiaFSR cell envelope str…

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