IL12RB1 Deficiency Appearing in North America: Expanding the Clinical Phenotypes

Overview of attention for article published in Clinical Infectious Diseases, November 2025

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IL-12Rβ1 deficiency causes Mendelian susceptibility to mycobacterial disease 🌍, often disseminated BCG infection. In N. America 🇺🇸, presents as other bacterial/fungal infections.

IL12RB1 deficiency is the most common genetic cause of susceptibility to mycobacterial disease, often seen as disseminated BCG infection. In North America, it presents with other infections. #idsky

RP @cidjournal.bsky.social: IL12RB1 deficiency appearing in North America: expanding the clinical phenotypes ✅ Just Accepted 🔗 https://bit.ly/4pjYo33

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