This is a shift in perspective: From “replace what is missing” to “rebalance the system” And that might be the more general lesson: In complex biological systems, disease is not always about absence. Sometimes it’s about proportion. Reference: http…
RT @Nature: Nature research paper: Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency https://t.co/gVw28zEawd
RT @VamsiMootha: Excited to share our new paper led by Josh Meisel w/ Gary Ruvkun. Worm suppressor genetics + biochemistry reveal that bala…
"Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency" Meisel JD [..] Ruvkun G, Mootha VK. Nature 2025-12-10. https://t.co/Of5ijlFHYL Models: C. elegans & mouse mutants generated with CRISPR-Cas9.