Re-evaluation of cellular radiosensitization by 5-fluorouracil: High-dose, pulsed administration is effective and preferable to conventional low-dose, chronic administration
Published in
International Journal of Radiation Biology, May 2013
It is widely believed that the anticancer drug 5- fluorouracil (5-FU) must be administered chronically and in low doses to maximize radiosensitization during chemoradiotherapy. The rationale is based upon cell experiments that assumed identical mechanisms of 5-FU action between low-dose chronic (LDC) and high-dose pulsed (HDP) exposures. Here we challenge the paradigm and demonstrate the effectiveness of HDP 5-FU as a radiosensitizer and the wide range of dose/time schedules that can be used to synergize with radiation as compared to the relatively restrictive protocols prescribed for current LDC administrations.
Pharmacology, Toxicology and Pharmaceutical Science
1
7%
Agricultural and Biological Sciences
1
7%
Neuroscience
1
7%
Unknown
6
43%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2013.
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#18,351,676
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Outputs from International Journal of Radiation Biology
#1,444
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#146,579
of 194,936 outputs
Outputs of similar age from International Journal of Radiation Biology
#11
of 20 outputs
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