This week's paper is by Daqi Li and Xiuxing Wang and team who show that tumour associated macrophages supply glioblastoma stem cells with lactate to promote their proliferation and induce KU70 lactylation to block cGAS-STING signalling and remodel the T…
Inhibiting macrophage-derived lactate transport restores cGAS–STING signaling and enhances antitumor immunity in glioblastoma @NatureCellBio https://t.co/roxYe5i8qR
グリオブラストーマにおいて、腫瘍随伴マクロファージ由来の乳酸輸送がDNA修復機構と免疫細胞浸潤を調節し、cGAS–STINGシグナル伝達および抗腫瘍免疫を抑制していることを明らかにした論文がNat Cell Biol誌に発表されました。 https://t.co/HG1b4cnmsj