TDP-43-mediated alternative polyadenylation is associated with a reduction in VPS35 and VPS29 expression in frontotemporal dementia

Overview of attention for article published in PLoS Biology, January 2026

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RP @charlottefare.bsky.social: TDP-43-mediated alternative polyadenylation is associated with a reduction in VPS35 and VPS29 expression in frontotemporal dementia dx.plos.org/10.1371/jour...

TDP-43-mediated alternative polyadenylation is associated with a reduction in VPS35 and VPS29 expression in frontotemporal dementia dx.plos.org/10.1371/jour...

journals.plos.org/plosbiology/...

RP @plosbiology.org: TDP-43 loss in frontotemporal #dementia (FTD) changes alternative polyA, but what are the consequences? This study shows that 3′UTR lengthening of VPS35 in #FTD patient brains correlates with reduced VPS35 & VPS29 levels, potentially …

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