Pilot investigations have suggested that a novel, long-acting, injectable, intra-muscular formulation of omeprazole (LA-OMEP) can induce acid suppression for up to 7 days following a single injection.
To investigate the pharmacodynamics and assess the clinical efficacy of the LA-OMEP formulation.
Part A) A pharmacodynamic study; Part B) A pilot clinical trial.
Part A) Six adult, Thoroughbred horses with percutaneous gastrotomy tubes were used. Intra-gastric pH was measured for continuous 23 hour periods (08.00 am - 07.00 am) for 8 consecutive days (days 0-7). A single 2.0 g dose of a 100 mg/mL, LA-OMEP formulation was administered at 08.00 am on day 1. Part B) Twenty-six horses with squamous or glandular gastric disease were enrolled based on routine gastroscopic evaluation. Once enrolled horses received 2.0 g of the 100 mg/mL LA-OMEP formulation by intra-muscular injection on days 0 and 7. Repeat gastroscopy was performed on day 14 (23 horses) or 16 (one horse).
Part A) The percentage of time pH was above 4 exceeded 66% for days 1-4 in all horses, and for days 1-7 in 4/6 horses studied. Part B) Healing was observed in 22/22 (100%: 95%CI 89 - 100%) horses with squamous disease, and 9/12 (75%: 95%CI 47 - 92%) horses with glandular disease. Improvement, by at least one grade, was observed in 22/22 (100%: 95%CI 89 - 100%) horses with squamous disease, and 12/12 (100%: 95%CI 81 - 100%) horses with glandular disease. Worsening of lesions was not observed. Lesion grade decreased over time for both the squamous (p<0.0001) and glandular mucosa (p = 0.0024).
Small sample sizes.
The results of the present study compare favourably with previous reports for the pharmacodynamics of omeprazole and clinical outcomes for trials reporting the response to oral omeprazole therapy. This article is protected by copyright. All rights reserved.
Pharmacology, Toxicology and Pharmaceutical Science
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Nursing and Health Professions
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Other
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Unknown
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Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2017.
All research outputs
#7,369,919
of 27,915,365 outputs
Outputs from Equine Veterinary Journal
#430
of 2,329 outputs
Outputs of similar age
#99,032
of 334,607 outputs
Outputs of similar age from Equine Veterinary Journal
#9
of 17 outputs
Altmetric has tracked 27,915,365 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 2,329 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 81% of its peers.
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
