Hearing loss is widespread and persistent because mature mammalian auditory hair cells (HCs) are nonregenerative. In mice, the ability to regenerate HCs from surrounding supporting cells (SCs) declines abruptly after postnatal maturation. We find that combining p27(Kip1) deletion with ectopic ATOH1 expression surmounts this age-related decline, leading to conversion of SCs to HCs in mature mouse cochleae and after noise damage. p27(Kip1) deletion, independent of canonical effects on Rb-family proteins, upregulated GATA3, a co-factor for ATOH1 that is lost from SCs with age. Co-activation of GATA3 or POU4F3 and ATOH1 promoted conversion of SCs to HCs in adult mice. Activation of POU4F3 alone also converted mature SCs to HCs in vivo. These data illuminate a genetic pathway that initiates auditory HC regeneration and suggest p27(Kip1), GATA3, and POU4F3 as additional therapeutic targets for ATOH1-mediated HC regeneration.
Pharmacology, Toxicology and Pharmaceutical Science
3
3%
Other
5
5%
Unknown
28
28%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 513. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2025.
All research outputs
#62,005
of 34,241,800 outputs
Outputs from Cell Reports
#66
of 16,767 outputs
Outputs of similar age
#1,096
of 353,787 outputs
Outputs of similar age from Cell Reports
#2
of 241 outputs
Altmetric has tracked 34,241,800 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 16,767 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.9. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 241 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.
