Amino acid-derived ionizable lipids enable inhaled base editing for therapeutic gene correction in the lung

Overview of attention for article published in Nature Materials, April 2026

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@midwit_capital Would highlight this paper, worth a read but I’m sure there are many others https://t.co/u6Rp1B3TmG

"Amino acid-derived ionizable lipids enable inhaled base editing for therapeutic gene correction in the lung" Gong F, Xu Y [..] Li B. Nat Mater. 2026-04-01. https://t.co/y8VScVPvau ... delivery of ABE mRNA & guide RNA to correct the CFTR G542X mut…

RT @PMResearch_UHN: Our scientists developed an amino acid–based lipid nanoparticle, inhalable to deliver mRNA into the lung, which correct…

肺疾患の遺伝子治療に使う薬剤を肺へ特異的に送達するための生分解性ナノ粒子素材を開発した論文。アミノ酸の構造を含む脂質「CHCha-10」がが送達性と安定性を両立する重要な構成要素で、気管からの投与で治療できることを動物試験で示しています。 Nature Materials誌 http…

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