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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
|
|---|---|
| Published in |
Nature, December 2013
|
| DOI | 10.1038/nature12822 |
| Pubmed ID | |
| Authors |
Maofu Liao, Erhu Cao, David Julius, Yifan Cheng |
| Abstract |
Transient receptor potential (TRP) channels are sensors for a wide range of cellular and environmental signals, but elucidating how these channels respond to physical and chemical stimuli has been hampered by a lack of detailed structural information. Here we exploit advances in electron cryo-microscopy to determine the structure of a mammalian TRP channel, TRPV1, at 3.4 Å resolution, breaking the side-chain resolution barrier for membrane proteins without crystallization. Like voltage-gated channels, TRPV1 exhibits four-fold symmetry around a central ion pathway formed by transmembrane segments 5-6 (S5-S6) and the intervening pore loop, which is flanked by S1-S4 voltage-sensor-like domains. TRPV1 has a wide extracellular 'mouth' with a short selectivity filter. The conserved 'TRP domain' interacts with the S4-S5 linker, consistent with its contribution to allosteric modulation. Subunit organization is facilitated by interactions among cytoplasmic domains, including amino-terminal ankyrin repeats. These observations provide a structural blueprint for understanding unique aspects of TRP channel function. |
X Demographics
The data shown below were collected from the profiles of 55 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 22% |
| United Kingdom | 3 | 5% |
| Japan | 2 | 4% |
| Australia | 2 | 4% |
| Germany | 2 | 4% |
| Indonesia | 1 | 2% |
| Peru | 1 | 2% |
| Spain | 1 | 2% |
| France | 1 | 2% |
| Other | 4 | 7% |
| Unknown | 26 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 36 | 65% |
| Scientists | 13 | 24% |
| Science communicators (journalists, bloggers, editors) | 6 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,582 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 13 | <1% |
| United Kingdom | 9 | <1% |
| Chile | 6 | <1% |
| Japan | 3 | <1% |
| Germany | 3 | <1% |
| Denmark | 3 | <1% |
| France | 2 | <1% |
| Switzerland | 2 | <1% |
| Netherlands | 2 | <1% |
| Other | 10 | <1% |
| Unknown | 1529 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 391 | 25% |
| Researcher | 295 | 19% |
| Student > Bachelor | 205 | 13% |
| Student > Master | 158 | 10% |
| Student > Doctoral Student | 73 | 5% |
| Other | 190 | 12% |
| Unknown | 270 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 464 | 29% |
| Biochemistry, Genetics and Molecular Biology | 383 | 24% |
| Chemistry | 126 | 8% |
| Neuroscience | 74 | 5% |
| Medicine and Dentistry | 70 | 4% |
| Other | 163 | 10% |
| Unknown | 302 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 169. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2024.
All research outputs
#245,682
of 25,870,142 outputs
Outputs from Nature
#13,973
of 98,981 outputs
Outputs of similar age
#2,129
of 322,355 outputs
Outputs of similar age from Nature
#171
of 956 outputs
Altmetric has tracked 25,870,142 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,981 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.8. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,355 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 956 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.