IQGAP3 bridges matrix stiffness with glioma stem cell maintenance and radioresistance by stabilizing SOX2

Overview of attention for article published in Nature Communications, June 2026

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Led by Dr. Jeremy Rich, a research team at @UPMCHillmanCC has shown that matrix stiffness drives #glioblastoma stem cell maintenance and radioresistance through an IQGAP3–SOX2 axis, revealing a potential strategy to enhance radiotherapy response. 🔖 http…

📢 New in @NatureComms! Researchers led by Dr. Jeremy Rich at @UPMCHillmanCC have shown that increased tumor stiffness drives glioblastoma #radioresistance by inducing IQGAP3-dependent stabilization of SOX2 in cancer stem cells. Read the study: https:/…

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