| Title |
High mixed venous oxygen saturation levels do not exclude fluid responsiveness in critically ill septic patients
|
|---|---|
| Published in |
Critical Care, July 2011
|
| DOI | 10.1186/10326 |
| Pubmed ID | |
| Authors |
Dimitrios Velissaris, Charalampos Pierrakos, Sabino Scolletta, Daniel De Backer, Jean Louis Vincent |
| Abstract |
ABSTRACT: INTRODUCTION: The aim of the study was to determine whether the degree of fluid responsiveness in critically ill septic patients is related to baseline mixed venous oxygen saturation (SvO2) levels. We also sought to define whether fluid responsiveness would be less likely in the presence of a high SvO2 (>70%). METHODS: This observational study was conducted in a 32-bed, university hospital medico-surgical intensive care unit (ICU). The hemodynamic response to a fluid challenge was evaluated in 65 critically ill patients with severe sepsis. Patients were divided into two groups (responders and non-responders) according to their cardiac index (CI) response to the challenge (>or < 10%). RESULTS: Of the 65 patients, 34 (52%) were fluid responders. Baseline SvO2, CI, heart rate (HR), and mean arterial pressure (MAP) were not statistically different between groups. The responders had lower pulmonary artery occlusion pressure (PAOP) and central venous pressure (CVP) at baseline than the non-responders. After the fluid challenge, there were no differences between the two groups in MAP, CVP, PAOP or HR. There was no correlation between changes in CI or stroke volume index (SVI) and baseline SvO2. ROC analysis showed that SvO2 was not a predictor of fluid responsiveness. CONCLUSIONS: The response of septic patients to a fluid challenge is independent of baseline SvO2. The presence of a high SvO2 does not necessarily exclude the need for further fluid administration. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 2% |
| Netherlands | 1 | 2% |
| France | 1 | 2% |
| Bulgaria | 1 | 2% |
| Canada | 1 | 2% |
| Denmark | 1 | 2% |
| Unknown | 50 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 25% |
| Other | 10 | 18% |
| Student > Postgraduate | 10 | 18% |
| Student > Master | 4 | 7% |
| Student > Ph. D. Student | 3 | 5% |
| Other | 8 | 14% |
| Unknown | 7 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 42 | 75% |
| Arts and Humanities | 1 | 2% |
| Decision Sciences | 1 | 2% |
| Agricultural and Biological Sciences | 1 | 2% |
| Unknown | 11 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2013.
All research outputs
#15,740,505
of 25,374,917 outputs
Outputs from Critical Care
#5,131
of 6,554 outputs
Outputs of similar age
#88,563
of 130,750 outputs
Outputs of similar age from Critical Care
#26
of 44 outputs
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