Title |
The Role of Oxidative Stress in the Clinical Manifestations of Childhood Asthma
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Published in |
Fetal & Pediatric Pathology, May 2017
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DOI | 10.1080/15513815.2017.1315199 |
Pubmed ID | |
Authors |
Aleksandra Topic, Djordje Francuski, Aleksandra Nikolic, Katarina Milosevic, Snezana Jovicic, Bojan Markovic, Mirjana Djukic, Dragica Radojkovic |
Abstract |
The significance of oxidative stress in pathogenesis of childhood asthma was recognized, but its role in the clinical manifestations of disease is still unclear. The study was conducted in 96 asthmatic children. The urinary biomarker of oxidative stress, 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG/creatinine) was determined by using HPLC-MS/MS. ELISA was performed to measure myeloperoxidase (MPO) and Cu,Zn- superoxide dismutase (Cu,Zn-SOD) in serum. Logistic regression analysis revealed that female gender, tobacco smoke exposure, and increased 8-oxodG/creatinine were associated with risk for intermittent asthma, while the positive allergy test and increased Cu,Zn-SOD were associated with eczema in asthmatic children. Higher MPO (p = 0.033), and percent of granulocytes (p = 0.030) were found in severe persistent asthma in comparison to intermittent or mild persistent asthma. The main findings that TSE-induced oxidative stress is a risk for intermittent asthma and eczema may be clinically significant for the disease prevention and therapeutic improvements. |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 24 | 100% |
Demographic breakdown
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Researcher | 6 | 25% |
Student > Ph. D. Student | 4 | 17% |
Student > Doctoral Student | 2 | 8% |
Student > Master | 2 | 8% |
Professor | 1 | 4% |
Other | 2 | 8% |
Unknown | 7 | 29% |
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Medicine and Dentistry | 3 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
Nursing and Health Professions | 2 | 8% |
Agricultural and Biological Sciences | 2 | 8% |
Other | 3 | 13% |
Unknown | 8 | 33% |