Title |
Long-term dietary l-arginine supplementation increases endothelial nitric oxide synthase and vasoactive intestinal peptide immunoexpression in rat small intestine
|
---|---|
Published in |
European Journal of Nutrition, October 2013
|
DOI | 10.1007/s00394-013-0585-8 |
Pubmed ID | |
Authors |
Ksenija Velickovic, Milica Markelic, Igor Golic, Vesna Otasevic, Ana Stancic, Aleksandra Jankovic, Milica Vucetic, Biljana Buzadzic, Bato Korac, Aleksandra Korac |
Abstract |
Nitric oxide (NO) and vasoactive intestinal polypeptide (VIP) are important intestinal neurotransmitters that coexist in the gut enteric nervous system and play an important role in intestinal physiology (e.g., absorption, motility, fluid secretion and smooth muscle relaxation). It is also known that cold exposure alters several aspects of gastrointestinal physiology and induces hyperphagia to meet increased metabolic demands, but there are no data regarding NO and VIP involvement in intestinal response during acclimation to cold. The objective of this study was to determine the influence of long-term L-arginine supplementation on the expression of the three isoforms of nitric oxide synthase (NOS) and VIP in small intestine of rats acclimated to room temperature or cold. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 22% |
Student > Bachelor | 4 | 17% |
Student > Postgraduate | 2 | 9% |
Student > Master | 2 | 9% |
Student > Ph. D. Student | 1 | 4% |
Other | 1 | 4% |
Unknown | 8 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 17% |
Agricultural and Biological Sciences | 3 | 13% |
Nursing and Health Professions | 2 | 9% |
Chemistry | 2 | 9% |
Immunology and Microbiology | 1 | 4% |
Other | 3 | 13% |
Unknown | 8 | 35% |