Previous electrophysiological work has demonstrated expression of a voltage-gated Na+ channel (VGSC) specifically in two highly metastatic prostatic epithelial tumour cell lines: MAT-LyLu (rat) and PC-3 (human). However, the identity of the channel(s) present was uncertain. The present study used a combination of molecular biological techniques to demonstrate that full-length skeletal muscle type 1 (SkM1) VGSC mRNA is present in the mRNA pool of the MAT-LyLu cell line. mRNA for this particular channel type was also expressed in the PC-3 cells. In situ hybridisation data suggested that the level and pattern of rSkM1 mRNA expression were different in the Dunning cells of markedly different metastatic potential. Interestingly, the same type of mRNA was also detected in the weakly metastatic counterparts of the cells: AT-2 (rat) and LNCaP (human).
Pharmacology, Toxicology and Pharmaceutical Science
2
11%
Biochemistry, Genetics and Molecular Biology
2
11%
Physics and Astronomy
1
6%
Other
0
0%
Unknown
3
17%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2024.
All research outputs
#5,140,457
of 34,358,242 outputs
Outputs from Febs Letters
#1,882
of 17,624 outputs
Outputs of similar age
#6,576
of 53,336 outputs
Outputs of similar age from Febs Letters
#44
of 443 outputs
Altmetric has tracked 34,358,242 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,624 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 53,336 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 443 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.
