Endothelial dysfunction predicts mortality but it is unknown whether childhood obesity predicts adult endothelial dysfunction. The aim of this study was to determine whether anthropometric indices of body fat in childhood, adolescence and early midlife are associated with endothelial dysfunction in early midlife.
Participants belonged to a representative birth cohort of 1037 individuals born in Dunedin, New Zealand in 1972 and 1973 and followed to age 38 years, with 95% retention (the Dunedin Multidisciplinary Health and Development Study). We assessed anthropometric indices of obesity at ages 3, 5, 7, 9, 11, 13, 15, 18, 21, 26, 32 and 38 years. We tested associations between endothelial function assessed by peripheral arterial tonometry at age 38 and; age-38 cardiovascular risk factors; age-3 body mass index (BMI); and four BMI trajectory groups from childhood to early midlife.
Early midlife endothelial dysfunction was associated with BMI, large waist circumference, low high-density lipoprotein cholesterol, low cardiorespiratory fitness, and increased high-sensitivity C-reactive protein. After adjustment for sex and childhood socioeconomic status, 3-year-olds with BMI one standard deviation above the mean had Framingham-reactive hyperemia index ratios that were 0.10 below those with normal BMI (β=-0.10, 95% CI -0.17 to -0.03, P=0.007) at age 38. Cohort members in the 'overweight', 'obese', and 'morbidly obese' trajectories had Framingham-reactive hyperemia index ratios that were 0.08 (β=-0.08, 95% CI -0.14 to -0.03, P=0.003), 0.13 (β=-0.13, 95% CI -0.21 to -0.06, P<0.001), and 0.17 (β=-0.17, 95% CI -0.33 to -0.01, P=0.033), respectively, below age-peers in the 'normal' trajectory.
Childhood BMI and the trajectories of BMI from childhood to early midlife predict endothelial dysfunction evaluated by peripheral arterial tonometry in early midlife.International Journal of Obesity accepted article preview online, 03 May 2017. doi:10.1038/ijo.2017.108.
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2018.
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