Objective: This study examines the association of fitness on glycemic variability (GV) in adolescents with Type 1 Diabetes Mellitus (T1DM). GV has been associated with high frequency of hyper and hypoglycemia.Methods: Nineteen adolescents with T1DM, ages 14-19, underwent aerobic fitness testing to determine VO2 max. A continuous glucose monitor (CGM) was placed on each subject and worn for 3-5 days until a return visit when subjects underwent a one hour treadmill exercise session. Mean amplitude of glycemic excursion (MAGE) was calculated from the CGM data collected between the two study visits. Metabolic equivalent (MET), a measure of accumulated metabolic workload during the exercise session was calculated.Results: Mean VO2 max, was 46.6 ± 6.8 mL x kg-1 x min-1 with a range of 34.8 to 57.0. Participants METs during the exercise session was 577.2 ± 102.4 and ranged from 354.3 to 716.2. There was an inverse association between VO2 max and MAGE, r = -0.46 (95% CI: -0.01, -0.76; p-value =0.048). MET load and MAGE also had an inverse relationship, r = -0.48, (95% CI: -0.03, -0.77; p-value = 0.037).Conclusions: GV was inversely associated with fitness and MET load. Aerobic fitness should be promoted in adolescents with T1DM because of multiple beneficial effects but also for a possible association with GV, leading to fewer extremes in hypoglycemia and hyperglycemia.
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2022.
All research outputs
#9,881,710
of 33,087,078 outputs
Outputs from Endocrine Practice
#647
of 1,692 outputs
Outputs of similar age
#78,348
of 264,749 outputs
Outputs of similar age from Endocrine Practice
#8
of 21 outputs
Altmetric has tracked 33,087,078 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,692 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.8. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,749 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
