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Effects of toceranib phosphate (palladia) monotherapy on multidrug resistant lymphoma in dogs

Overview of attention for article published in Journal of Veterinary Medical Science, June 2017
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Title
Effects of toceranib phosphate (palladia) monotherapy on multidrug resistant lymphoma in dogs
Published in
Journal of Veterinary Medical Science, June 2017
DOI 10.1292/jvms.16-0457
Pubmed ID
Authors

Hiroki YAMAZAKI, Naoki MIURA, Yu-Chang LAI, Masashi TAKAHASHI, Yuko GOTO-KOSHINO, Momoi YASUYUKI, Munekazu NAKAICHI, Hajime TSUJIMOTO, Asuka SETOGUCHI, ENDO Yasuyuki

Abstract

We examined whether multidrug resistant (MDR) canine lymphoma increases gene expression for platelet-derived growth factor receptor α (PDGFRα), vascular endothelial growth factor receptor 2 (VEGFR2), and c-KIT, and whether toceranib phosphate (TOC) has potential as a treatment for MDR canine lymphoma. The clinical data showed that PDGFRα expression was higher in canine subjects with MDR T-cell lymphoma than in those with untreated T-cell lymphoma, and that c-KIT expression was greater in subjects with T-cell lymphoma than in those with B-cell lymphoma. TOC monotherapy was well tolerated without serious adverse effects, and two of the five subjects that received TOC exhibited partial responses. The data presented here could contribute to the assessment of TOC-based therapy for dogs with MDR or T-cell lymphoma.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 5 14%
Other 4 11%
Professor 3 9%
Student > Ph. D. Student 3 9%
Researcher 3 9%
Other 6 17%
Unknown 11 31%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 14 40%
Medicine and Dentistry 5 14%
Agricultural and Biological Sciences 3 9%
Nursing and Health Professions 2 6%
Social Sciences 1 3%
Other 0 0%
Unknown 10 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2018.
All research outputs
#16,051,091
of 25,382,440 outputs
Outputs from Journal of Veterinary Medical Science
#1,084
of 3,546 outputs
Outputs of similar age
#188,717
of 331,668 outputs
Outputs of similar age from Journal of Veterinary Medical Science
#14
of 82 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,546 research outputs from this source. They receive a mean Attention Score of 2.5. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,668 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.