| Title |
Visualization of microarray results to assist interpretation
|
|---|---|
| Published in |
Tuberculosis (formerly Tubercle and Lung Disease), January 2004
|
| DOI | 10.1016/j.tube.2003.12.012 |
| Pubmed ID | |
| Authors |
Irene Papatheodorou, Marek Sergot, Marty Randall, Graham R Stewart, Brian D Robertson |
| Abstract |
Whole genome microarrays allow assessment of the profile of genes expressed under particular experimental conditions, including external stimuli such as pH or temperature, and internal changes brought about by deleting or over-expressing a gene. Such experiments produce large data sets, for which sophisticated analysis software is available. What is lacking are tools for analysing data sets from different experiments, in order to test and generate hypotheses about the links between regulatory networks. We describe here a method for presenting results from different experiments as a directed graph constructed using an automated graph drawing program xneato, enhanced by a logic program designed to cluster data and aid in the generation of hypotheses about possible gene interactions. A web-based front-end to the system has been constructed to explore and manipulate the graphical displays produced. Results of microarray experiments on Mycobacterium tuberculosis were used to develop and evaluate the visualization tool and initiate the development of an inference system for gene interactions based on such data. The GeneGraph project can be accessed at: zebrafish.doc.ic.ac.uk |
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Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 4% |
| Unknown | 22 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 43% |
| Student > Ph. D. Student | 4 | 17% |
| Professor > Associate Professor | 3 | 13% |
| Professor | 2 | 9% |
| Student > Master | 2 | 9% |
| Other | 2 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 74% |
| Biochemistry, Genetics and Molecular Biology | 2 | 9% |
| Medicine and Dentistry | 2 | 9% |
| Computer Science | 1 | 4% |
| Immunology and Microbiology | 1 | 4% |
| Other | 0 | 0% |