| Title |
Varicella zoster virus vasculopathy: The expanding clinical spectrum and pathogenesis
|
|---|---|
| Published in |
Journal of Neuroimmunology, March 2017
|
| DOI | 10.1016/j.jneuroim.2017.03.014 |
| Pubmed ID | |
| Authors | |
| Abstract |
Varicella zoster virus (VZV) is a ubiquitous, human alphaherpesvirus that produces varicella on primary infection then becomes latent in ganglionic neurons along the entire neuraxis. In elderly and immunocompromised individuals, VZV reactivates and travels along nerve fibers peripherally resulting in zoster. However, VZV can also spread centrally and infect cerebral and extracranial arteries (VZV vasculopathy) to produce transient ischemic attacks, stroke, aneurysm, sinus thrombosis and giant cell arteritis, as well as granulomatous aortitis. The mechanisms of virus-induced pathological vascular remodeling are not fully elucidated; however, recent studies suggest that inflammation and dysregulation of programmed death ligand-1 play a significant role. |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 27% |
| United Kingdom | 1 | 9% |
| Chile | 1 | 9% |
| Canada | 1 | 9% |
| Unknown | 5 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 91% |
| Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 114 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 11% |
| Researcher | 12 | 11% |
| Other | 9 | 8% |
| Student > Doctoral Student | 8 | 7% |
| Student > Ph. D. Student | 8 | 7% |
| Other | 25 | 22% |
| Unknown | 39 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 49 | 43% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Neuroscience | 4 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Nursing and Health Professions | 3 | 3% |
| Other | 4 | 4% |
| Unknown | 45 | 39% |