Title |
Targeting Astrocytes for Treatment in Amyotrophic Lateral Sclerosis.
|
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Published in |
Current Pharmaceutical Design, January 2017
|
DOI | 10.2174/1381612823666170615110446 |
Pubmed ID | |
Authors |
Mina Peric, Dinko Mitrecic, Pavle R Andjus |
Abstract |
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder affecting upper and lower motoneurons. The two types, sporadic and familial differ in the aetiopathogenesis but have a similar neuropathology characterized by oxidative stress, excitotoxicity and inflammation. The disease is also characterized by a non-cell autonomous mechanism with astrocytes playing a central role by affecting synaptic glutamate, the blood-brain barrier, and metabolic and trophic support. Two types of therapeutic approaches focusing on astrocytes are presented: a) emerging molecular targets (potassium inward rectifier channels and aquaporins at the astrocyte endfeet, and IP3 receptor signaling pathway), and b) cell therapy with stem cell - generated and transplanted astrocytes. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 6 | 30% |
Student > Ph. D. Student | 2 | 10% |
Other | 1 | 5% |
Professor | 1 | 5% |
Student > Doctoral Student | 1 | 5% |
Other | 4 | 20% |
Unknown | 5 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 35% |
Neuroscience | 3 | 15% |
Agricultural and Biological Sciences | 2 | 10% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Chemistry | 1 | 5% |
Other | 0 | 0% |
Unknown | 6 | 30% |