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Mendeley readers
Attention Score in Context
| Title |
CarbORev‐5901: The First Carborane‐Based Inhibitor of the 5‐Lipoxygenase Pathway
|
|---|---|
| Published in |
ChemMedChem, June 2017
|
| DOI | 10.1002/cmdc.201700309 |
| Pubmed ID | |
| Authors |
Robert Kuhnert, Menyhárt‐Botond Sárosi, Sven George, Peter Lönnecke, Bettina Hofmann, Dieter Steinhilber, Blagoje Murganic, Sanja Mijatovic, Danijela Maksimovic‐Ivanic, Evamarie Hey‐Hawkins |
| Abstract |
The progression of cancer is accelerated by increased proliferation, angiogenesis, and inflammation. These processes are mediated by leukotrienes. Several cancer cell lines overexpress 5-lipoxygenase, an enzyme that converts arachidonic acid to leukotrienes. An early inhibitor of the 5-lipoxygenase pathway is Rev-5901, which, however, lacks in in vivo efficacy due to strong metabolisation. We investigated the introduction of carboranes as highly hydrophobic and metabolically stable pharmacophores into lipoxygenase inhibitors. Carboranes are icosahedral boron clusters that are remarkably stable and used in order to increase the metabolic stability of unstable pharmaceutics without changing their biological activity. By introduction of meta-carborane into Rev-5901, the first carborane-based inhibitor of the 5-lipoxygenase pathway was obtained. We report the synthesis, the inhibitory and cytotoxic behaviour of these compounds for several melanoma and colon cancer cell lines and their related anticancer mechanisms. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 21% |
| Student > Ph. D. Student | 4 | 21% |
| Other | 3 | 16% |
| Student > Master | 3 | 16% |
| Librarian | 1 | 5% |
| Other | 3 | 16% |
| Unknown | 1 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 7 | 37% |
| Medicine and Dentistry | 3 | 16% |
| Agricultural and Biological Sciences | 2 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 11% |
| Immunology and Microbiology | 1 | 5% |
| Other | 3 | 16% |
| Unknown | 1 | 5% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2019.
All research outputs
#6,867,734
of 24,578,676 outputs
Outputs from ChemMedChem
#930
of 3,504 outputs
Outputs of similar age
#103,159
of 321,366 outputs
Outputs of similar age from ChemMedChem
#16
of 57 outputs
Altmetric has tracked 24,578,676 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 3,504 research outputs from this source. They receive a mean Attention Score of 4.0. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,366 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.