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抗リウマチ薬投与中に発症した医原性免疫不全関連EBV陰性NK細胞性リンパ増殖性疾患

Overview of attention for article published in [Rinshō ketsueki] The Japanese journal of clinical hematology, July 2017
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Title
抗リウマチ薬投与中に発症した医原性免疫不全関連EBV陰性NK細胞性リンパ増殖性疾患
Published in
[Rinshō ketsueki] The Japanese journal of clinical hematology, July 2017
DOI 10.11406/rinketsu.58.624
Pubmed ID
Authors

Tomoyuki Uchida, Morihiro Inoue, Jian Hua, Shogo Tajima, Yasunori Ota, Masao Hagihara

Abstract

Here we present a patient with rheumatoid arthritis (RA), who was suspected to have developed malignant lymphoma during immunosuppressive therapy 5 years earlier. She temporarily achieved remission after discontinuing therapy; however, her disease worsened with remittent fever and splenomegaly. Splenic biopsy demonstrated infiltration by abnormal cells, which were positive for CD56 and T cell intracytoplasmic antigen, but negative for CD3 and Epstein-Barr virus (EBV) -encoded RNA. Cytogenetic analysis of bone marrow and lumbar spine tumor revealed common complex karyotype abnormalities. Thus, she was diagnosed with chronic natural killer cell lymphoproliferative disorder (NK-LPD) and finally died of disease progression. The most common type of LPD in methotrexate-related patients with RA is B-lymphoid LPD, whereas NK-LPD is extremely rare. Furthermore, almost all cases of NK-LPD have been reported to be positive for EBV. This is the first case report on a patient with EBV-negative NK-LPD developed during immunosuppressive therapy for RA.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 3 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 3 100%
Readers by discipline Count As %
Social Sciences 3 100%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2017.
All research outputs
#21,048,638
of 25,852,155 outputs
Outputs from [Rinshō ketsueki] The Japanese journal of clinical hematology
#345
of 727 outputs
Outputs of similar age
#253,108
of 326,912 outputs
Outputs of similar age from [Rinshō ketsueki] The Japanese journal of clinical hematology
#2
of 7 outputs
Altmetric has tracked 25,852,155 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 727 research outputs from this source. They receive a mean Attention Score of 1.5. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 326,912 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.