Developing evidence in the literature suggests that SIRT5 may be involved in metabolic reprogramming, an emerging hallmark of cancer by which neoplastic cells reconfigure their metabolism to support the anabolic demands of rapid cell division. Sirtuin 5 (SIRT5) is one of the seven members of the nicotinamide adenine dinucleotide (NAD+)-dependent sirtuin family of lysine deacylases. It removes succinyl, malonyl, and glutaryl groups from protein targets within the mitochondrial matrix and other subcellular compartments. SIRT5's substrates include a number of proteins integral to metabolism. Recent Advances: New work has begun to elucidate the roles of SIRT5 in glycolysis, TCA cycle, FAO, nitrogen metabolism, pentose phosphate pathway, antioxidant defense, and apoptosis.
Here, we summarize biological functions of SIRT5 reported in normal tissues and in cancer, and discuss potential mechanisms whereby SIRT5 may impact tumorigenesis, particularly focusing on its reported roles in metabolic reprogramming. Finally, we review current efforts to target SIRT5 pharmacologically.
The biological significance of SIRT5 has been elucidated in the context of only an extremely small fraction of its targets and interactors. No doubt further studies in this area will provide a wealth of insights into functions of SIRT5 and its targets in normal and neoplastic cells.
Pharmacology, Toxicology and Pharmaceutical Science
3
4%
Chemical Engineering
2
3%
Immunology and Microbiology
2
3%
Other
7
10%
Unknown
29
40%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2017.
All research outputs
#21,904,491
of 34,363,559 outputs
Outputs from Antioxidants & Redox Signaling
#1,609
of 2,399 outputs
Outputs of similar age
#220,517
of 377,555 outputs
Outputs of similar age from Antioxidants & Redox Signaling
#20
of 33 outputs
Altmetric has tracked 34,363,559 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,399 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 377,555 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
