Gastric slow wave dysrhythmias are accompanied by deviations in frequency, velocity, and extracellular amplitude, but the inherent association between these parameters in normal activity still requires clarification. This study quantified these associations using a joint experimental-theoretical approach.
Gastric pacing was conducted in pigs with simultaneous high-resolution slow wave mapping (32-256 electrodes; 4-7.6 mm spacing). Relationships between period, velocity, and amplitude were quantified and correlated for each wavefront. Human data from two existing mapping control cohorts were analyzed to extract and correlate these same parameters. A validated biophysically based ICC model was also applied in silico to quantify velocity-period relationships during entrainment simulations and velocity-amplitude relationships from membrane potential equations.
Porcine pacing studies identified positive correlations for velocity-period (0.13 mm s(-1) per 1 s, r(2) =.63, P<.001) and amplitude-velocity (74 μV per 1 mm s(-1) , r(2) =.21, P=.002). In humans, positive correlations were also quantified for velocity-period (corpus: 0.11 mm s(-1) per 1 s, r(2) =.16, P<.001; antrum: 0.23 mm s(-1) per 1 s, r(2) =.55; P<.001), and amplitude-velocity (94 μV per 1 mm s(-1) , r(2) =.56; P<.001). Entrainment simulations matched the experimental velocity-period relationships and demonstrated dependence on the slow wave recovery phase. Simulated membrane potential relationships were close to these experimental results (100 μV per 1 mm s(-1) ).
These data quantify the relationships between slow wave frequency, velocity, and extracellular amplitude. The results from both human and porcine studies were in keeping with biophysical models, demonstrating concordance with ICC biophysics. These relationships are important in the regulation of gastric motility and will help to guide interpretations of dysrhythmias.
Pharmacology, Toxicology and Pharmaceutical Science
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Linguistics
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Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2017.
All research outputs
#19,256,200
of 30,050,033 outputs
Outputs from Neurogastroenterology & Motility
#2,023
of 2,759 outputs
Outputs of similar age
#190,620
of 332,952 outputs
Outputs of similar age from Neurogastroenterology & Motility
#32
of 48 outputs
Altmetric has tracked 30,050,033 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,759 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
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We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
