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Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease

Overview of attention for article published in Cognitive and Behavioral Neurology, March 2014
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Title
Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease
Published in
Cognitive and Behavioral Neurology, March 2014
DOI 10.1097/wnn.0000000000000015
Pubmed ID
Authors

Nikola Veselinovic, Aleksandra M. Pavlovic, Boris Petrovic, Aleksandar Ristic, Ivana Novakovic, Tamara Svabic Medjedovic, Dragan Pavlovic, Nada Sternic

Abstract

Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease caused by conformational alteration of the ubiquitous prion protein. Sporadic CJD appears to progress faster if the basal ganglia are shown to be affected on magnetic resonance imaging. Transcranial B-mode sonography (TCS) enables visualization of differences in tissue echogenicity, which can be associated with changes in the cerebral metabolism of various metals. These metabolic changes are considered 1 of the potential mechanisms of the brain damage in CJD; TCS hyperechogenicity may reflect changes in metal homeostasis in CJD. We report a 63-year-old woman who presented with typical sporadic CJD. One month after she fell ill, a magnetic resonance imaging scan of her brain showed diffuse cortical but no obvious basal ganglia involvement. However, TCS revealed moderate hyperechogenicity of both lentiform nuclei. The patient's disease progressed quickly and she died 2 months later. TCS may show basal ganglia alteration early in the disease course of patients with quickly progressing CJD, thus aiding in premortem diagnosis.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 29%
Student > Bachelor 2 14%
Professor > Associate Professor 2 14%
Professor 1 7%
Researcher 1 7%
Other 1 7%
Unknown 3 21%
Readers by discipline Count As %
Medicine and Dentistry 5 36%
Biochemistry, Genetics and Molecular Biology 3 21%
Nursing and Health Professions 1 7%
Psychology 1 7%
Neuroscience 1 7%
Other 0 0%
Unknown 3 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 April 2014.
All research outputs
#20,653,708
of 25,371,288 outputs
Outputs from Cognitive and Behavioral Neurology
#268
of 324 outputs
Outputs of similar age
#174,502
of 236,356 outputs
Outputs of similar age from Cognitive and Behavioral Neurology
#3
of 4 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
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