Title |
Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease
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Published in |
Cognitive and Behavioral Neurology, March 2014
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DOI | 10.1097/wnn.0000000000000015 |
Pubmed ID | |
Authors |
Nikola Veselinovic, Aleksandra M. Pavlovic, Boris Petrovic, Aleksandar Ristic, Ivana Novakovic, Tamara Svabic Medjedovic, Dragan Pavlovic, Nada Sternic |
Abstract |
Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease caused by conformational alteration of the ubiquitous prion protein. Sporadic CJD appears to progress faster if the basal ganglia are shown to be affected on magnetic resonance imaging. Transcranial B-mode sonography (TCS) enables visualization of differences in tissue echogenicity, which can be associated with changes in the cerebral metabolism of various metals. These metabolic changes are considered 1 of the potential mechanisms of the brain damage in CJD; TCS hyperechogenicity may reflect changes in metal homeostasis in CJD. We report a 63-year-old woman who presented with typical sporadic CJD. One month after she fell ill, a magnetic resonance imaging scan of her brain showed diffuse cortical but no obvious basal ganglia involvement. However, TCS revealed moderate hyperechogenicity of both lentiform nuclei. The patient's disease progressed quickly and she died 2 months later. TCS may show basal ganglia alteration early in the disease course of patients with quickly progressing CJD, thus aiding in premortem diagnosis. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 14 | 100% |
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Student > Ph. D. Student | 4 | 29% |
Student > Bachelor | 2 | 14% |
Professor > Associate Professor | 2 | 14% |
Professor | 1 | 7% |
Researcher | 1 | 7% |
Other | 1 | 7% |
Unknown | 3 | 21% |
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Biochemistry, Genetics and Molecular Biology | 3 | 21% |
Nursing and Health Professions | 1 | 7% |
Psychology | 1 | 7% |
Neuroscience | 1 | 7% |
Other | 0 | 0% |
Unknown | 3 | 21% |