| Title |
Cell Replacement Strategies Aimed at Reconstitution of the β-Cell Compartment in Type 1 Diabetes
|
|---|---|
| Published in |
Diabetes, April 2014
|
| DOI | 10.2337/db13-1742 |
| Pubmed ID | |
| Authors | |
| Abstract |
Emerging technologies in regenerative medicine have the potential to restore the β-cell compartment in diabetic patients, thereby overcoming the inadequacies of current treatment strategies and organ supply. Novel approaches include: 1) Encapsulation technology that protects islet transplants from host immune surveillance; 2) stem cell therapies and cellular reprogramming, which seek to regenerate the depleted β-cell compartment; and 3) whole-organ bioengineering, which capitalizes on the innate properties of the pancreas extracellular matrix to drive cellular repopulation. Collaborative efforts across these subfields of regenerative medicine seek to ultimately produce a bioengineered pancreas capable of restoring endocrine function in patients with insulin-dependent diabetes. |
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Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Italy | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 102 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 21% |
| Student > Bachelor | 15 | 14% |
| Researcher | 14 | 13% |
| Student > Master | 11 | 10% |
| Other | 9 | 9% |
| Other | 19 | 18% |
| Unknown | 15 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 24% |
| Biochemistry, Genetics and Molecular Biology | 20 | 19% |
| Agricultural and Biological Sciences | 18 | 17% |
| Engineering | 6 | 6% |
| Immunology and Microbiology | 3 | 3% |
| Other | 14 | 13% |
| Unknown | 19 | 18% |