| Title |
An integrated approach for the in vitro dosimetry of engineered nanomaterials
|
|---|---|
| Published in |
Particle and Fibre Toxicology, May 2014
|
| DOI | 10.1186/1743-8977-11-20 |
| Pubmed ID | |
| Authors |
Joel M Cohen, Justin G Teeguarden, Philip Demokritou |
| Abstract |
There is a great need for screening tools capable of rapidly assessing nanomaterial toxicity. One impediment to the development of reliable in vitro screening methods is the need for accurate measures of cellular dose. We present here a methodology that enables accurate determination of delivered to cell dose metrics. This methodology includes (1) standardization of engineered nanomaterial (ENM) suspension preparation; (2) measurement of ENM characteristics controlling delivery to cells in culture; and (3) calculation of delivered dose as a function of exposure time using the ISDD model. The approach is validated against experimentally measured doses, and simplified analytical expressions for the delivered dose (Relevant In Vitro Dose (RID)f function) are derived for 20 ENMs. These functions can be used by nanotoxicologists to accurately calculate the total mass (RIDM), surface area (RIDSA), or particle number (RIDN) delivered to cells as a function of exposure time. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Belgium | 2 | 2% |
| Germany | 1 | <1% |
| Colombia | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 125 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 31 | 23% |
| Student > Ph. D. Student | 28 | 21% |
| Student > Master | 20 | 15% |
| Other | 9 | 7% |
| Student > Bachelor | 5 | 4% |
| Other | 20 | 15% |
| Unknown | 19 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 17% |
| Chemistry | 16 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 10% |
| Engineering | 11 | 8% |
| Environmental Science | 10 | 8% |
| Other | 33 | 25% |
| Unknown | 27 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2014.
All research outputs
#18,371,959
of 22,755,127 outputs
Outputs from Particle and Fibre Toxicology
#423
of 560 outputs
Outputs of similar age
#164,646
of 227,857 outputs
Outputs of similar age from Particle and Fibre Toxicology
#4
of 4 outputs
Altmetric has tracked 22,755,127 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 560 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.2. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,857 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.