The Interaction Between Epidural 2-Chloroprocaine and Morphine: A Randomized Controlled Trial of the Effect of Drug Administration Timing on the Efficacy of Morphine Analgesia
The efficacy and duration of epidural morphine analgesia is diminished when administered after 2-chloroprocaine compared with lidocaine. The mechanism of the interaction between 2-chloroprocaine and morphine is unknown. Possible explanations include differences in the latency and duration of action of the two drugs or opioid receptor antagonism. We hypothesized that administration of epidural morphine 30 min before the initiation of 2-chloroprocaine anesthesia would result in postoperative analgesia of similar duration and quality to that achieved by epidural morphine after the initiation of lidocaine anesthesia in patients undergoing postpartum tubal ligation.
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2009.
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#24,751,637
of 34,358,242 outputs
Outputs from Anesthesia and analgesia
#8,829
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#154,784
of 173,975 outputs
Outputs of similar age from Anesthesia and analgesia
#53
of 64 outputs
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